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STOCK-RAISING AND VETERINARY

ANALYSIS OF CANDIDATE GENES ASSOCIATED WITH PRODUCTIVITY IN THE SARYARKA FAT-TAILED COARSE-WOOLED SHEEP BREED (INTRA-BREED ZHANAARKA TYPE)

Ainur Orakbayeva 1 , Kairat Dosybayev 2 , Sholpan Adylkanova 1 , Altynai Kozhakhmet 3 , Marina Yermekova 2 , Tilek Kapasuly 3 , Makpal Amandykova 3

1 NJSC "Kazakh National Agrarian Research University"; 2 LLP "Kazakh Research Institute of Livestock and Foraging"; 3 RSE "Institute of Genetics and Physiology" of the CS MES RK

doi.org/10.37884/3-2025/06 pp. 55-64 Admitted 19.07.2025 Published 30.09.2025

Abstract

The Saryarka sheep breed is one of the fat-tailed, coarse-wool sheep breeds raised in Kazakhstan, known for its high meat productivity and fertility. Live weight and morphometric traits (body indices) are essential phenotypic indicators in breeding programs, especially for improving meat yield.This study aimed to identify genome-wide associations (GWAS) between SNP markers and live weight as well as five major morphometric traits (interzygomatic width, loin width, chest girth, and cannon bone girth) in the Saryarka sheep breed. Blood samples were collected from 60 animals, genomic DNA was extracted, and genotyping was performed using the OvineSNP50 Genotyping BeadChip. GWAS analysis identified significant SNP markers associated with each trait.The identified markers were annotated to the Ovis aries genome (Oar_v3.1) using the BioMart platform. As a result, six candidate genes IGFBP6, ST7, SCD5, DTNBP1, KYNU, and FTO were found to be associated with live weight and four morphometric traits. These genes are involved in growth regulation, lipid metabolism, tissue development, and immune responses, and are consistent with findings from similar studies in other sheep breeds.The results of this study provide molecular markers associated with meat productivity in the Saryarka sheep breed, establishing a scientific foundation for the development of marker-assisted selection. This opens the way for targeted and efficient genetic improvement in sheep breeding.

 

Saryarka fat-tailed coarse-wool sheep breed SNP meat productivity GWAS candidate genes

01 Introduction

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02 References

  1. 1. Адылканова Ш. Р., Садыкулов Т. С., Орақбаева А. Д., Сансызбаева Б. Қ. Формирование мясной продуктивности ягнят сарыаркинской курдючной породы овец (внутрипородный жанааркинский тип) // Ізденістер, нәтижелер– 2023. – № 4 (100). – С. 20–27. – DOI: https://doi.org/10.37884/4-2023/03
  2. 2. Visscher P.M., Wray N.R., Zhang Q., Sklar P., McCarthy M.I., Brown M.A., Yang J. 10 years of GWAS discovery: biology, function, and translation // Nature Reviews Genetics. – 2017. – Vol. 18, No. 2. – P. 117–127.
  3. 3. Kirichenko A.V., Zlobin A.S., Shashkova T.I., Volkova N.A., Iolchiev B.S., Bagirov V.A., Borodin P.M., Karssen L.S., Tsepilov Y.A., Aulchenko Y.S. The GWAS-MAP|ovis platform for aggregation and analysis of genome-wide association study results in sheep. – 2022. – Preprint.
  4. 4. Kirichenko A.V., Zlobin A.S., Shashkova T.I., Volkova N.A., Iolchiev B.S., Bagirov V.A., Borodin P.M., Karssen L.S., Tsepilov Y.A., Aulchenko Y.S. The GWAS-MAP|ovis platform for aggregation and analysis of genome-wide association study results in sheep. – 2022. – Preprint.
  5. 5. Bolormaa S., et al. A genome-wide association study of meat and carcass traits in sheep // Genetics Selection Evolution. – 2016. – Vol. 48. – P. 38.
  6. 6. Zhang L., Liu J., Zhao F., Ren H., Xu L., Lu J., Zhang S., Zhang X., Wei C., Lu G., Zheng Y., Du L. Genome-wide association studies for growth and meat production traits in sheep // PLOS ONE. – 2013. – Vol. 8(6). – e66569.
  7. 7. Riggio V., Pong-Wong R., Sallé G., et al. A genome-wide association study for wool, skin, and body weight traits in sheep // PLOS ONE. – 2013. – Vol. 8(12). – e81956.
  8. 8. Садыкулов Т. С., Адылканова Ш. Р. Селекционно-генетические аспекты совершенствования курдючных пород овец: монография. – Алматы: Альманах, 2022. – 180 с.
  9. 9. Jiang J., Cao Y., Shan H., Wu J., Song X., Jiang Y. The GWAS analysis of body size and population verification of related SNPs in Hu sheep // Animals. – 2022. – Vol. 12(20). -P. 2792. https://doi.org/10.3390/ani12202792
  10. 10. Abdoli R., Mirhoseini S.Z., Ghavi Hossein-Zadeh N., Zamani P., Ferdosi M.H., Gondro C. Genome-wide association study of four composite reproductive traits in Iranian fat-tailed sheep // Reproduction, Fertility and Development. – 2019. – Vol. 31(8). – P. 1305–1314. https://doi.org/10.1071/RD18282
  11. 11. Al-Mamun H.A., Kwan P., Clark S.A., Ferdosi M.H., Tellam R., Gondro C. Genome-wide association study of body weight in Australian Merino sheep reveals an orthologous region on OAR6 to human and bovine genomic regions affecting height and weight // Genetics Selection Evolution. – 2015. – Vol. 47. – P. 66.
  12. 12. Ghasemi M., Hossein-Zadeh N.G., Zamani P. Identification of candidate genes and pathways affecting meat quality traits in sheep using GWAS and bioinformatics analysis // Animal Genetics. – 2020. – Vol. 51. – P. 678–689
  13. 13. Kijas J.W., Lenstra J.A., Hayes B., Boitard S., et al. Genome-wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection // PLOS Biology. – 2012. – Vol. 10(2). – e1001258.
  14. 14. Andersson L., Archibald A.L., Bottema C.D., et al. Coordinated international action to accelerate genome-to-phenome with FAANG, the Functional Annotation of Animal Genomes project // Genome Biology. – 2015. – Vol. 16. – P. 57.
  15. 15. Meuwissen, T. H. E., Hayes, B. J., & Goddard, M. E. (2013). Accelerating improvement of livestock with genomic selection. Annual Review of Animal Biosciences, 1, 221–237.
  16. 16. Садықұлов Т.С., Ким Г.Л., Жазылбеков Қ.З., Имашев С.Д., Бұралқиев Б.А. Ауыл шаруашылық жануарларын өсіру және селекциялау: оқу құралы. – Павлодар: Кереку, 2003. – 29–34-бб.
  17. 17. PLINK1.9Home. Available online: https://www.cog-genomics.org/plink/ (accessed on 14 April 2025)
  18. 18. Ensembl. Available online: http://www.ensembl.org/biomart/martview/ (accessed on 14 April 2025).
  19. 19. The R Project for Statistical Computing. Available online: https://www.r-project.org/ (accessed on 14 April 2024)

Citation Links

[1]2025. ANALYSIS OF CANDIDATE GENES ASSOCIATED WITH PRODUCTIVITY IN THE SARYARKA FAT-TAILED COARSE-WOOLED SHEEP BREED (INTRA-BREED ZHANAARKA TYPE). Izdenister natigeler. 3 (107) (Sep. 2025), 55–64. DOI:https://doi.org/10.37884/3-2025/06.
(1)ANALYSIS OF CANDIDATE GENES ASSOCIATED WITH PRODUCTIVITY IN THE SARYARKA FAT-TAILED COARSE-WOOLED SHEEP BREED (INTRA-BREED ZHANAARKA TYPE). Izdenister natigeler 2025, No. 3 (107), 55-64. https://doi.org/10.37884/3-2025/06.
ANALYSIS OF CANDIDATE GENES ASSOCIATED WITH PRODUCTIVITY IN THE SARYARKA FAT-TAILED COARSE-WOOLED SHEEP BREED (INTRA-BREED ZHANAARKA TYPE). (2025). Izdenister Natigeler, 3 (107), 55-64. https://doi.org/10.37884/3-2025/06
ANALYSIS OF CANDIDATE GENES ASSOCIATED WITH PRODUCTIVITY IN THE SARYARKA FAT-TAILED COARSE-WOOLED SHEEP BREED (INTRA-BREED ZHANAARKA TYPE). Izdenister natigeler, [S. l.], n. 3 (107), p. 55–64, 2025. DOI: 10.37884/3-2025/06. Disponível em: https://kazvetjournal.kaznaru.edu.kz/index.php/research/article/view/1060. Acesso em: 15 sep. 2026.
“ANALYSIS OF CANDIDATE GENES ASSOCIATED WITH PRODUCTIVITY IN THE SARYARKA FAT-TAILED COARSE-WOOLED SHEEP BREED (INTRA-BREED ZHANAARKA TYPE)”. 2025. Izdenister Natigeler, no. 3 (107) (September): 55-64. https://doi.org/10.37884/3-2025/06.
“ANALYSIS OF CANDIDATE GENES ASSOCIATED WITH PRODUCTIVITY IN THE SARYARKA FAT-TAILED COARSE-WOOLED SHEEP BREED (INTRA-BREED ZHANAARKA TYPE)” (2025) Izdenister natigeler, (3 (107), pp. 55–64. doi:10.37884/3-2025/06.
[1]“ANALYSIS OF CANDIDATE GENES ASSOCIATED WITH PRODUCTIVITY IN THE SARYARKA FAT-TAILED COARSE-WOOLED SHEEP BREED (INTRA-BREED ZHANAARKA TYPE)”, Izdenister natigeler, no. 3 (107), pp. 55–64, Sep. 2025, doi: 10.37884/3-2025/06.
“ANALYSIS OF CANDIDATE GENES ASSOCIATED WITH PRODUCTIVITY IN THE SARYARKA FAT-TAILED COARSE-WOOLED SHEEP BREED (INTRA-BREED ZHANAARKA TYPE)”. Izdenister Natigeler, no. 3 (107), Sept. 2025, pp. 55-64, https://doi.org/10.37884/3-2025/06.
“ANALYSIS OF CANDIDATE GENES ASSOCIATED WITH PRODUCTIVITY IN THE SARYARKA FAT-TAILED COARSE-WOOLED SHEEP BREED (INTRA-BREED ZHANAARKA TYPE)”. Izdenister natigeler, no. 3 (107) (September 30, 2025): 55–64. Accessed September 15, 2026. https://kazvetjournal.kaznaru.edu.kz/index.php/research/article/view/1060.
1.ANALYSIS OF CANDIDATE GENES ASSOCIATED WITH PRODUCTIVITY IN THE SARYARKA FAT-TAILED COARSE-WOOLED SHEEP BREED (INTRA-BREED ZHANAARKA TYPE). Izdenister natigeler [Internet]. 2025 Sep. 30 [cited 2026 Sep. 15];(3 (107):55-64. Available from: https://kazvetjournal.kaznaru.edu.kz/index.php/research/article/view/1060
1.ANALYSIS OF CANDIDATE GENES ASSOCIATED WITH PRODUCTIVITY IN THE SARYARKA FAT-TAILED COARSE-WOOLED SHEEP BREED (INTRA-BREED ZHANAARKA TYPE). Izdenister natigeler. 2025;(3 (107):55-64. doi:10.37884/3-2025/06