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INVESTIGATION OF THE INDICATORS OF ACUTE, CUMULATIVE AND CHRONIC TOXICITY OF A POLYCOMPONENT PHYTOPREPARATION

Nurtleu Zamanbekov 1 , Khudaibergen Azizov 1 , Sobiech Przemyslaw 2 , Yerganat Korabaev 1 , Nurzila Kobdikova 1 , Shirin Turzhigitova 1 , Marzhan Baimurzayeva 1

1 NJSC «Kazakh National Agrarian Research University» ; 2 University of Warmia and Mazury in Olsztyn

doi.org/10.37884/3-2024/01 pp. 5-15 Admitted 29.08.2024 Published 30.09.2024

Abstract

The article examines in detail the indicators of acute, cumulative and chronic toxicity of a complex phytopreparation and its individual components made from the collection of medicinal plants with medicinal properties. The data obtained as a result of the study showed that the complex phytopreparation and its individual components, when administered intramuscularly and orally, do not cause the death of laboratory animals. After the introduction of plant extracts in animals, reactions occurred instantly and manifested themselves in the form of short-term anxiety. Clinical signs of mild intoxication last 5-7 minutes, and then completely stop. To study the possible consequences of the metatoxic effect of phytopreparation components, no obvious pathological abnormalities in internal organs were revealed during pathoanatomic autopsies. The pathological picture in the compared groups was of the same type and no special signs were revealed. As a result of data analysis, it was revealed that repeated administration of a phytopreparation in high doses leads to a decrease in body weight of mice in the test groups. This indicator was especially observed when the phytopreparation was administered at a dose of 1.0 ml daily for 30 days, the absolute decrease in body weight of mice in the test group was 10.7% of the background values, and compared with the indicators of the control and intact groups, its significant decrease was observed, on average to 8.9%. Studies have found that a multicomponent phytopreparation in optimal doses has a stimulating effect on the morphological and biochemical parameters of the blood of laboratory animals, and in high doses, on the contrary, an inhibitory effect.

multicomponent phytopreparation, extract, toxicity, cumulation, morphological index, biochemical index.

01 Introduction

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02 References

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Citation Links

[1]2024. INVESTIGATION OF THE INDICATORS OF ACUTE, CUMULATIVE AND CHRONIC TOXICITY OF A POLYCOMPONENT PHYTOPREPARATION. Izdenister natigeler. 3(103) (Sep. 2024), 5–15. DOI:https://doi.org/10.37884/3-2024/01.
(1)INVESTIGATION OF THE INDICATORS OF ACUTE, CUMULATIVE AND CHRONIC TOXICITY OF A POLYCOMPONENT PHYTOPREPARATION. Izdenister natigeler 2024, No. 3(103), 5-15. https://doi.org/10.37884/3-2024/01.
INVESTIGATION OF THE INDICATORS OF ACUTE, CUMULATIVE AND CHRONIC TOXICITY OF A POLYCOMPONENT PHYTOPREPARATION. (2024). Izdenister Natigeler, 3(103), 5-15. https://doi.org/10.37884/3-2024/01
INVESTIGATION OF THE INDICATORS OF ACUTE, CUMULATIVE AND CHRONIC TOXICITY OF A POLYCOMPONENT PHYTOPREPARATION. Izdenister natigeler, [S. l.], n. 3(103), p. 5–15, 2024. DOI: 10.37884/3-2024/01. Disponível em: https://kazvetjournal.kaznaru.edu.kz/index.php/research/article/view/703. Acesso em: 15 sep. 2026.
“INVESTIGATION OF THE INDICATORS OF ACUTE, CUMULATIVE AND CHRONIC TOXICITY OF A POLYCOMPONENT PHYTOPREPARATION”. 2024. Izdenister Natigeler, no. 3(103) (September): 5-15. https://doi.org/10.37884/3-2024/01.
“INVESTIGATION OF THE INDICATORS OF ACUTE, CUMULATIVE AND CHRONIC TOXICITY OF A POLYCOMPONENT PHYTOPREPARATION” (2024) Izdenister natigeler, (3(103), pp. 5–15. doi:10.37884/3-2024/01.
[1]“INVESTIGATION OF THE INDICATORS OF ACUTE, CUMULATIVE AND CHRONIC TOXICITY OF A POLYCOMPONENT PHYTOPREPARATION”, Izdenister natigeler, no. 3(103), pp. 5–15, Sep. 2024, doi: 10.37884/3-2024/01.
“INVESTIGATION OF THE INDICATORS OF ACUTE, CUMULATIVE AND CHRONIC TOXICITY OF A POLYCOMPONENT PHYTOPREPARATION”. Izdenister Natigeler, no. 3(103), Sept. 2024, pp. 5-15, https://doi.org/10.37884/3-2024/01.
“INVESTIGATION OF THE INDICATORS OF ACUTE, CUMULATIVE AND CHRONIC TOXICITY OF A POLYCOMPONENT PHYTOPREPARATION”. Izdenister natigeler, no. 3(103) (September 30, 2024): 5–15. Accessed September 15, 2026. https://kazvetjournal.kaznaru.edu.kz/index.php/research/article/view/703.
1.INVESTIGATION OF THE INDICATORS OF ACUTE, CUMULATIVE AND CHRONIC TOXICITY OF A POLYCOMPONENT PHYTOPREPARATION. Izdenister natigeler [Internet]. 2024 Sep. 30 [cited 2026 Sep. 15];(3(103):5-15. Available from: https://kazvetjournal.kaznaru.edu.kz/index.php/research/article/view/703
1.INVESTIGATION OF THE INDICATORS OF ACUTE, CUMULATIVE AND CHRONIC TOXICITY OF A POLYCOMPONENT PHYTOPREPARATION. Izdenister natigeler. 2024;(3(103):5-15. doi:10.37884/3-2024/01